支气管肺发育不良“血管假说”及促血管生成治疗进展

摘要

Bronchopulmonary dysplasia (BPD) is a chronic pulmonary disease which seriously affects the survival and long term quality of life in premature infants. Its pathogenesis is not yet clear. In recent years, the role of pulmonary vascular dysplasia in BPD has received increasing attention and evolved into a“vascular hypothesis”of the pathogenesis of BPD. Angiogenesis therapy based on this hypothesis has also made some progress in the treatment of BPD. This paper brielfy reviews the current research situation in this ifeld.%支气管肺发育不良（BPD）是严重影响早产儿生存及远期生活质量的慢性肺部疾病，其发病机制尚未明确。近年来，肺血管发育不良在BPD中的作用机制日益受到重视，并发展为BPD发病的“血管假说”，以此为理论依据的促血管生成治疗也在BPD中取得了一定的进展。文章就该领域研究现状作一综述。