儿童吉兰-巴雷综合征恢复独立行走能力的短期预后因素分析

摘要

目的 探讨儿童吉兰-巴雷综合征(GBS)的短期预后因素.方法 纳入125例GBS患儿,根据在出院后第2个月和第6个月是否可以独立行走进行分组,并比较分析其临床资料.结果 125例患儿中男74例、女51例,平均年龄(84.49 ± 25.32)月,6岁以下儿童41例.102例患儿有前驱感染病史.颅神经受累32例,自主神经受累35例.需要辅助呼吸12例.出院后第2和第6个月,不能独立行走患儿的功能评分>3分、颅神经受累、神经电生理为失神经电位型的比例均高于能独立行走的患儿,差异有统计学意义(P<0.05).结论 影响患儿短期预后的因素为神经电生理为失神经电位型,颅神经受累及功能评分>3.应早期识别不同的患儿,并进行针对性康复训练,改善预后.%Objective To explore the prognostic factors in Guillain Barre syndrome (GBS) in children. Methods A total of 125 children with GBS were included and grouped according to their independent walking at two and six months after discharge, and their clinical data were analyzed. Results In 125 children (74 males, 51 females) the average age was 84.49±25.32 months, and 41 were under 6 years old. 102 children had a history of prodromal infections. 32 children had cranial nerve involvement and 35 had autonomic nerve involvement. 12 children need assisted respiration. At 2 and 6 months after discharge, when compared with children who could walk independently, the rates of functional score > 3, cranial nerve involvement, and neuroelectrophysiology as denervation potential were higher in children who could not walk independently, and the differences were statistically significant (P all<0.05). Conclusions The factors that affect the short-term prognosis are denervation potential in neuroelectrophysiology, cranial nerve involvement, and functional score > 3. Early identification of uniqueness in patients and subsequent development of targeted rehabilitation training should be carried out to improve the prognosis.