原发性中枢神经系统非霍奇金淋巴瘤的影像学特征

摘要

Objective To explore the imaging features of patients with primary non-Hodgkin's lymphoma of the central nervous system(PCNSNHL).Methods Clinical data of 12 patients with PCNSNHL were analyzed retrospectively.Results MRI showed equal or lower signal on T 1WI, and equal or higher signal on T 2WI.The space-occupying lesion showed massive homogeneous enhancement and peripheral edema,and the range of edema was disproportionate to lesion size.The dynamic enhanced MRI of space-occupying lesion in early stage showed low signal on T1,high signal on T2.1H-magnetic resonance spectroscopy(1 H-MRS)of 5 cases showed choline(Cho)peak of enhanced regions was significantly increased, and N-acetyla spartate(NAA)peak of enhanced regions was significantly decreased.Conclusions MRI features of PCNSNHL are"sharp angle sign","notch sign"on enhanced T1, or inhomogeneous enhancement.1H-MRS shows choline(Cho)peak of enhanced regions is significantly increased,and N-acetyla spartate(NAA)peak of enhanced regions is significantly decreased,even has lipid peak.%目的 探讨原发性CNS非霍奇金淋巴瘤(PCNSNHL)的影像学特征.方法 回顾性分析12例PCNSNHL患者的临床资料.结果 本组患者MRI检查示T1等或低信号,T2等或高信号;占位病灶呈均匀团块样强化,周围水肿,且水肿范围与病变大小不成比例;占位病灶早期动态增强示T1低信号,T2高信号.5例患者行质子核磁共振光谱成像(1 H-MRS)示强化区胆碱峰明显升高,N-乙酰天冬氨酸峰明显降低.结论 PCNSNHL的MRI主要特征为T1增强出现"尖角征"、"脐凹征"征,或表现为不规则强化;1H-MRS表现为胆碱峰明显升高,N-乙酰天冬氨酸峰明显降低,甚至出现脂质峰.