目的 分析9年间血培养检出菌构成的变化及常见细菌的耐药情况,并对抽血前经验应用抗生素情况进行回顾性分析.方法 总结我院1999～2007年间外科术后血培养252株检出菌、药敏结果以及经验性应用抗生素情况.结果 凝固酶阴性葡萄球菌(CNS)居多;在金黄色葡萄球菌、溶血葡萄球菌、表皮葡萄球菌中,目前尚未发现对万古霉素耐药的菌株;在大肠埃希氏菌、阴沟肠杆菌、克雷伯杆菌中,目前尚未发现耐亚胺培南的菌株;没有发现对氟康唑耐药的白色假丝酵母菌菌株.结论 凝固酶阴性葡萄球菌是血培养常见菌株,万古霉素是非常有效的抗葡萄球菌药物;对于大肠埃希氏菌、阴沟肠杆菌、克雷伯杆菌,亚胺培南仍是最有效的抗生素;对于白色念珠菌菌株氟康唑仍是有效的药物.%Objective To investigate the changes of bacteria detected from blood culture and results of antibiotic resistance. Methods Postoperative 252 bacterial isolates were obtained from blood culture and the clinical application of antibiotics were analyzed. Results Coagulase negative Staphylococci (CNS) was largest in the past ten years. In Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus epidermidis,no vancomycin-resistant strains were found. In Escherichia Klebsiella, Enter-obacter cloacae, Klebsiella, no imipenem-resistant strains were found. No fluconazole-resistant strains of Candida albicans were found. Conclusions Coagulase-negative staphylococci is common blood culture I-solate. At present,vancomycin is very effective anti-staphylococcal drug. In Escherichia Klebsiella,Enter-obacter cloacae,Klebsiella,imipenem remains the most effective. Fluconazole is still effective medicine to the Candida albicans. With the extensive application of broad-spectrum antibiotics, fungal infections become a serious problem.
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