吡咯喹啉醌生理医学功效研究进展

摘要

Pynoloquinoline quinone (PQQ) is a small molecular quinone compound. As designated in earlier literature, this bacterial-ly synthesized quinone acts as a redox cofactor of bacterial dehydrogenases, and exists in the various organism tissues. This article presented a brief review on valuable studies related to its physiology and medicine effect (primarily including neurodegenerative disease, heart disease, detoxification, anti-inflammatory, anticancer, prevention of cataract and metabolic bone disease) and assessed the potential for further clinical application. Moreover, the prospect of future research of PQQ in the physiological ecology of aquatic organisms was discussed.%吡咯喹啉醌(PQQ)是一种小分子醌类化合物,由某些细菌合成作为细菌脱氢酶氧化还原反应的辅助因子,并广泛存在于各种生物组织中.综述了其在生理医学功效方面的研究进展情况,分析其在神经退行性疾病、心脏病、解毒、消炎、抗癌、预防白内障及骨代谢疾病等方面的临床应用潜力,并对其未来在水生生物生理生态学领域的研究方向进行了展望.