丙型肝炎病毒5个基因的正选择位点研究

摘要

The positively selected sites for the five major genes (E1, E2, NS3, NS5A and NS5B) of HCV were analyzed from the perspective of time and subtype, and the pattern of variation of these positively selected sites was studied. The Result of this assay showed that the five genes were generally subject to purifying selection (mean Ω < 1), and the order of the purifying selection pressure on them was E2