慢性乙型肝炎患者在不同肝功能情况下外周血中的T淋巴细胞亚群、补体C3、补体C4及HBV-DNA的比较

摘要

目的 比较慢性乙型肝炎(CHB)患者在不同肝功能情况下外周血中T淋巴细胞亚群,补体C3、C4与HBV-DNA.方法 选取136例CHB患者,根据治疗前后肝功能变化情况将患者分为好转组和恶化组.检测2组患者外周血中T淋巴细胞亚群,补体C3、C4和HBV-DNA.结果 好转组72例,恶化组64例,恶化组患者与好转组患者CD3+比较,差异无统计学意义(P>0.05).恶化组患者与好转组患者比较,CD4+明显减少,而CD8+明显增加,同时CD4+/CD8+比值明显下降,差异均有统计学意义(P<0.05).恶化组患者补体C3、C4水平相较于好转组均有不同程度的下降,差异均有统计学意义(t=12.124、P=0.003,t=4.041、P=0.010).好转组患者和恶化组患者HBV-DNA比较,差异无统计学意义(t=-2.598、P=0.793).结论 相比于补体C4、T细胞亚群和HBV-DNA,补体C3水平更能反映CHB患者肝功能损伤的情况.%Objective To compare the T-lymphocyte subpopulations,complement C3,C4 and HBV-DNA in the peripheral blood of patients with chronic hepatitis B under different liver function.Methods A total of 136 patients with chronic hepatitis B were selected,the patients were divided into improved group and deteriorated group according to the changes of hepatic function.T-lymphocyte subpopulations,complement C3,complement C4 and HBV-DNA in two groups were determined.Results A total of 72 patients were included in improved group,64 patients were included in deteriorated group.CD4+ in deteriorated group was significantly decreased,and CD8+ was significantly increased compared with those in improved group(P<0.05),CD3+ had no statistical difference between the two groups(P>0.05).Complement C3 and complement C4 in deteriorated group decreased compared with those in the improved group(t=12.124,P=0.003;t=4.041,P=0.010).However,HBV-DNA had no statistical difference between two groups(t=-2.598,P=0.793 ).Conclusion Compared with T-lymphocyte subpopulations,complement C4 and HBV-DNA,complement C3 has a better sensitivity to reflect the damage of the hepatic function in patients with chronic hepatitis B.