血清霉菌特异性IgE阳性支气管哮喘患者的临床及过敏状态分析

摘要

ObjectiveTo investigate the clinical and allergic patients with serum mold speciifc IgE positive in bronchial asthma.Methods70 patients with bronchial asthma who had received diagnosis and treatments in our hospital were chosen as research objects. The blood samples were collected from these patients and were processed with normal centrifugation (2000 r/min, 10 min) to separate serum samples. Serum mold speciifc IgE were tested with Solid phase enzyme dot technology.ResultsAmong 70 patients, 9 were conifrmed with mold positive, the positive rate of speciifc IgE is 12.86%; among 70 patients, 7 were conifrmed with mold positive during April to October and 2 were conifrmed with mold positive during November to March. The differences are statistical significant.ConclusionsThe mold is one of the allergic sources of bronchial asthma and can influence the disease in a seasonal trend. Detection of serum mold speciifc IgE plays an important role in the clinical diagnosis, treatment and prevention of bronchial asthma, it also provides valuable laboratory data for asthma epidemiology.%目的：探讨分析血清霉菌特异性IgE阳性支气管哮喘患者的临床及过敏状态。方法选取2010年1月至2013年1月在我院接受诊断和治疗的支气管哮喘患者70例为研究对象，抽取所有受试者的静脉血液，将血液样本进行常规离心（2000 r/min，10 min）处理后分离血清样本。使用固相酶斑点技术测定血清中霉菌过敏原特异性IgE。结果70例患者中9例检测出霉菌，特异性IgE阳性率为12.86%；70例患者中在4~10月中检出霉菌的为7例占17.07%，在11~3月份检出霉菌的为2例占6.90%，4~10月的检出率明显高于11~3月， P<0.05，差异统计学显著。结论霉菌是过敏性支气管哮喘的致敏原之一，并呈现季节性变化。血清霉菌特异性IgE的检测对临床诊断、治疗和预防支气管哮喘有重要意义，也为哮喘的流行病学提供了宝贵的实验室数据。