The acute toxicity of KMnO4 ,PVP-I ,and BCDMH to sand worm Perinereis aibuhitensis were studied at 25-26 ℃ by a static test method . The results showed that the toxicity order of the three disinfectants to the san worm was ranged as KMnO4 > BCDMH > PVP-I . The medium lethal concentrations (LC50 ) of KMnO4 to the san worm were found to be 18 .7 mg/L in 24 h ,11 .8 mg/L in 48 h , and 7 .2 mg/L in 96 h ,the LC50 of PVP-I 632 .9 mg/L in 24 h ,492 mg/L in 48 h ,and 420 .6 mg/L in 96 h ,and the LC50 BCDMH 560 .5 mg/L in 24 h ,283 mg/L in 48 h and 190 mg/L in 96 h with safe concentration (SC) of 1 .4 mg/L ,89 .1 mg/L and 21 .6 mg/L for the three disinfectants ,respectively .It is recommended that KMnO4 be used carefully , while BCDMH and PVP-I are proposed to be ideal disinfectant in the breeding and disease control of P .aibuhitensis .%为探明高锰酸钾、聚维酮碘、溴氯海因对双齿围沙蚕的毒性影响及安全质量浓度，采用静水生物毒性测试法，分别用高锰酸钾、聚维酮碘、溴氯海因3种消毒药物对双齿围沙蚕进行急性毒性试验。试验结果表明，毒性为高锰酸钾＞溴氯海因＞聚维酮碘。高锰酸钾对沙蚕24、48、96 h的半致死质量浓度分别为18．7、11．8、7．2 mg/L ，聚维酮碘对沙蚕24、48、96 h的半致死质量浓度分别为632．9、492、420．6 mg/L ，溴氯海因对沙蚕24、48、96 h的半致死质量浓度分别为560．5、283、190 mg/L。这3种消毒药物的安全质量浓度分别为：高锰酸钾1．4mg/L，聚维酮碘89．1mg/L，溴氯海因21．6mg/L。溴氯海因和聚维酮碘在双齿围沙蚕养殖生产和病害防治中是较为理想的消毒药物。
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