Risk and Cumulative Risk of Acute Ischemic Stroke Recurrence in China:A Systematic Review and Meta-Analysis

摘要

Objective:To comprehensively evaluate the risk of recurrence after initial ischemic stroke,and to provide a relatively comprehensive reference for the prevention and control of stroke recurrence.Methods:CNKI,VIP,Wanfang,PubMed,Web of Science,Embase and other databases were collected to investigate the status of recurrence after initial ischemic stroke,the search period of which was from the establishment of databases to March 2019.And then quality evaluation and data extraction were carried out.The overall cumulative risks of stroke recurrence at 3 months,6 months,1 year,2 years and 5 years after initial ischemic stroke were calculated,and heterogeneity analysis was performed.Results:A total of 29 studies from 19 provinces(cities,autonomous regions)in China were included.The cumulative total sample size was 22484 cases,the cumulative recurrent sample size was 3309 cases.The pooled cumulative risk was 4.5%(95%CI:3.1-5.8)at 3 months,7.8%(95%CI:5.6-10.0)at 6 months,13.6%(95%CI:11.0-16.2)at 1 year,17.5%(95%CI:12.4-22.6)at 2 years and 30.9%(95%CI:20.2-41.7)at 5 years after initial ischemic stroke.Conclusions:The recurrence rate of acute ischemic stroke in China is high.It is recommended that all levels of medical and health departments strengthen the prevention and treatment of ischemic stroke recurrence to reduce the recurrence of ischemic stroke and improve the prognosis of patients.