目的 探讨平均血小板体积与淋巴细胞比值(mean platelet volume to lymphocyte ratio,MPVLR)与急性冠脉综合征(acute coronary syndrome,ACS)患者冠脉病变严重程度的相关性.方法 选取行冠脉造影确诊的95例ACS作为观察组,选择同期入院的可疑冠心病而冠脉造影正常的非冠心病54例作为对照组.按照SYNTAX评分将观察组分为低危组(＜23分,n=57)和高危组(≥23分,n=38).记录患者的一般资料,检测平均血小板体积(mean platelet volume,MPV)、淋巴细胞计数、尿酸等实验室指标,计算MPVLR,分析MPVLR对ACS患者冠脉病变的独立预测价值.结果 三组年龄、男性比例、高血压病史、糖尿病史、病变血管数、左室射血分数、肌酐、尿酸、MPVLR比较差异有统计学意义(P＜0.05).logistic回归分析显示,病变血管数、MPVLR为影响ACS患者冠脉病变严重程度的独立危险因素(P＜0.05).结论 MPVLR是ACS患者冠脉病变严重程度的独立危险因素,可作为评估ACS患者预后的预测指标之一.%Objective To investigate the correlation between mean platelet volume-to-lymphocyte ratio (MPVLR) and the severity of coronary artery lesion in patients with acute coronary syndrome (ACS). Methods A total of 95 patients with ACS confirmed by coronary angiography (CAG) were enrolled as observation group, while 54 patients without coronary heart disease (CHD) who underwent CAG after admission to our hospital for suspicious CHD during the same period were selected as the control group.According to the SYNTAX score, the observation group was subdivided into low risk group (＜23 points, n=57) and high risk group (≥23 points, n=38). General data of all patients were documented. In all patients, laboratory indicators such as the mean platelet volume (MPV), lymphocyte count and uric acid were detected and MPVLR was calculated. The independent predictive value of MPVLR for coronary artery lesions in ACS patients was analyzed.Results There were significant differences in age, male ratio, history of hypertension, history of diabetes, number of diseased vessels, left ventricular ejection fraction, creatinine, uric acid, and MPVLR in the three groups (P＜0.05). Logistic regression analysis showed that number of diseased vessels and MPVLR were independent risk factors for severity of coronary artery lesions in ACS patients (P＜0.05). Conclusion MPVLR is an independent risk factor for severity of coronary artery lesions in patients with ACS and can be used as one of predictors for the prognosis of those patients.
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