中西药降脂方案联合运动治疗代谢综合征临床效果观察

摘要

目的 探讨中西药降脂方案联合运动治疗代谢综合征的临床效果.方法 选择我院2017年2月—2018年4月收治的代谢综合征90例,按照随机数字表法分为观察组和对照组,每组各45例.对照组予常规治疗和中西药降脂方案,观察组在此基础上加以运动治疗,两组均治疗12周.检测两组身体形态指标(体质量指数、体脂率、腰围)、血脂[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血压、空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(HOMA-IR)等水平变化,记录临床疗效,观察不良反应发生情况.结果 与本组治疗前比较,两组治疗后体重、腰围、体质量指数、体脂率、收缩压、舒张压、FPG、TG、TC、LDL-C、FINS及HOMA-IR均降低,HDL-C升高,差异有统计学意义(P＜0.05);与对照组比较,观察组治疗后体重、腰围、体质量指数、体脂率、收缩压、FPG、TG、TC、LDL-C、FINS及HOMA-IR下降更为显著,HDL-C明显升高,差异有统计学意义(P＜0.05).两组不良反应发生情况比较差异无统计学意义(P＞0.05).结论 中西药降脂方案联合运动治疗代谢综合征能更好地降低体脂率和体质量指数,改善血清学各项指标,临床效果好.%Objective To investigate the clinical effect of lipid-lowering regimen by TCM and Western medicine combined with exercise on metabolic syndrome. Methods A total of 90 cases of patients with metabolic syndrome treated in in our hospital from February 2017 to April 2018 were randomly divided into the experimental group (n=45) and the control group (n=45). The control group was given conventional medical treatment and lipid-lowering regimen by TCM and Western medicine for symptomatic treatment. On this basis, the experimental group was given additional exercise treatment Both groups were treated for 12 weeks. The changes of the body shape indicators [body mass index (BMI), body fat percentage (BFP), waist circumference (WC) ], blood lipids [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) ], blood pressure (BP), fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment-insulin resistance index (HOMA-IR) were detected before and after treatment. In addition, the clinical therapeutic effects and adverse effects of the two groups were recorded and evaluated. Results Compared with those before treatment, the body weight, WC, BMI, BFP, systolic blood pressure (SBP), diastolic blood pressure (DBP), FPG, TG, TC, LDL-C, FINS and HOMA-IR were all decreased after treatment, while HDL-C was increased, suggesting significant differences (P＜0.05). Compared with those in the control group, body weight, WC, BMI, BFP, SBP, FPG, TG, TC, LDL-C and HOMA-IR was more significantly decreased in the observed group after treatment, whereas HDL-C was significantly increased, and the difference was statistically significant (P＜0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion lipid-lowering regimen by TCM and Western medicine combined with exercise for the treatment of metabolic syndrome can better reduce BFP and BMI, improve the serological indicators, and have a good clinical effect.