高尿酸血症与高原地区急性心肌梗死发病的关系

摘要

目的 探讨高原地区急性心肌梗死(acute myocardial infarction, AMI)的发生发展与血尿酸水平的关系.方法 对2007年1月～2010年5月我院58例AMI(观察组)与62例健康体检者(对照组)进行血尿酸值的检测并对比分析.同时将观察组根据梗死面积分为轻度组(1个梗死面)30例、重度组(≥2个梗死面或出现严重并发症)28例,比较病情程度及预后与血尿酸的关系.结果 观察组血尿酸平均(438±94)μmol/L,对照组平均(312±92)μmol/L,两组比较差异有统计学意义 (t=7.42,P<0.05).观察组中,重度组平均血尿酸(498±94)μmol/L,轻度组平均(415±89)μmol/L,两组比较差异有统计学意义 (t=3.45,P<0.05).结论 高尿酸血症是高原地区AMI的危险因素之一,血尿酸水平与高原地区AMI的发生、发展及预后有明显的相关性.%Objective To investigate the relationship between Acute Myocardial Infarction(AMI) and serum uric acid level in highland regions. Methods 58 cases of AMI( observation group) and 62 healthy adults who underwent medical examination( control group) during January 2007 and May 2010 received serum uric acid test, and the results were compared. The patients in observation group were divided into low-grade group( with only one region of infarct, n=30 ) and high-grade group( with more than 2 regions of infarct or severe complications, n = 28 ), and the relation of genetic condition, prognosis and serum uric acid levels were compared. Results The average uric acid levels in observation group was (438 ±94) μmol/L, and (312 ±92) μ mol/L in the control group, and there was significant difference between the two groups(t =7.42,P ＜0.05). The average uric acid levels in fantasy group 1 was (498 ±94) μ. mol/L, and (415 ± 89) μmol/L in low-grade group, and there was significant difference between the two groups( t=3.45,P ＜0.05 ). Conclusion Hyperuricemia is one of the important risk factors of AMI in highland region, and serum uric acid levels are significantly related with occurrence, progress and prognosis of AMI.