Objective To explore the clinical efficacy of 10% 5-aminolaevulinic acid photodynamic therapy ( ALA-PDT) combined with collagen dressing in the treatment of moderate to severe acne. Methods 160 patients with moderate to severe acne admitted during January 2010 and June 2011 in our hospital were divided into therapy group and control group (n = 80) according to digital numbers. Patients in therapy group were given 10% ALA-PDT combined with collagen dressing, while patients in control group were only given 10% ALA- PDT. The patients'therapeutic efficacy was evaluated after treatment for 8 weeks. Adverse effects of the two groups were also recorded in therapeutic process. Results The cure rate was 50. 63% and total efficacy rale was 86.08% in therapy group while the cure rate was 40. 51% and total efficacy rate was 72. 15% in control group. The difference between the two groups in the cure rate was not statistically significant (χ2 = 1.29, P > 0.05) , while the difference in total efficacy rate was statistically significant (χ2 =4.63, P<0. 05). Conclusion Photodynamic therapy with 10% 5-aminolevulinic acid combined with collagen dressing is a simple and effective treatment for moderate to severe acne with fewer side reactions.%目的 探讨10％5-氨基酮戊酸光动力联合胶原蛋白贴治疗中重度痤疮的临床疗效.方法 选择我院2010年1月-2011年6月收治的160例中重度痤疮,按照数字编号随机分为治疗组与对照组.治疗组80例,予10％5-氨基酮戊酸光动力联合胶原蛋白贴治疗；对照组80例,仅予10％5-氨基酮戊酸光动力治疗,8周后进行总体评估,并记录两组治疗过程中出现的不良反应.结果 治疗组痊愈率50.63％,总有效率86.08％,对照组痊愈率40.51％,总有效率72.15％,两组痊愈率比较差异无统计学意义(x2=1.29,P＞0.05),总有效率比较差异有统计学意义(x2=4.63,P＜0.05).结论 10％5-氨基酮戊酸光动力联合胶原蛋白贴治疗中重度痤疮可提高疗效,并减少不良反应.
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