血清MMP-3和TIMP-1水平在子宫内膜异位症诊断中的意义

摘要

Objective To evaluate significance of levels of serum matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in diagnosis of endometriosis.Methods A total of 46 patients with endometriosis (observation group) and 40 healthy women (control group) were recruited in this study.Serum levels of MMP-3 and TIMP-1 in the two groups were measured and compared.Results Serum levels of MMP-3 and TIMP-I in observation group were (139.7 ±71.0)μg/L and (340.8 ± 111.5)μg/L,and (70.5 ±32.0)μg/L and (188.9 ±72.8)μg/L in control group respectively.The differences of the two groups were statistically significant (P ＜ 0.01).Area under receiver operating characteristic (ROC) curves of serum MMP-3 and TIMP-1 were 0.831 and 0.864 respectively (P ＜ 0.01).The sensitivity of combined detection of serum MMP-3 and TIMP-1 was 97.4％,and specificity was 96.3％.Serum levels of TIMP-1 showed positive correlation with MMP-3 (r =0.5003,P ＜0.01).Conclusion MMP-3 and TIMP-1 may be related to the progression of endometriosis,and serum levels of MMP-3 and TIMP-1 may be helpful in diagnosis and adjuvant approaches of endometriosis.%目的 探讨血清基质金属蛋白酶3(matrix metalloproteinase-3,MMP-3)和基质金属蛋白酶组织抑制因子1(tissue inhibitor of matrix metalloproteinase-1,TIMP-1)在子宫内膜异位症诊断中的意义.方法 选取46例子宫内膜异位症为观察组,40例健康体检女性作为对照组.测定两组血清MMP-3和TIMP-1水平并进行比较.结果 血清MMP-3和TIMP-1水平观察组分别为(139.7±71.0) μg/L、(340.8±111.5) μg/L,对照组分别为(70.5±32.0) μg/L、(188.9±72.8) μg/L,两组比较差异均有统计学意义(P＜0.01).患者血清MMP-3和TIMP-1的ROC曲线下面积分别为0.831和0.864,差异有统计学意义(P＜0.01),两者联合检测诊断子宫内膜异位症灵敏度为97.4％,特异度为96.3％.相关分析显示,血清TIMP-1与MMP-3水平呈正相关(r=0.5003,P＜0.01).结论 MMP-3和TIMP-1可能与子宫内膜异位症的发生、发展有关,血清MMP-3和TIMP-1检测可作为该病诊断的辅助手段.