Objective In order to improve understanding of the POEMS syndrome, we explored the main clinical fea-tures of the disease. Methods Clinical data of five patients diagnosed with the POEMS syndrome, during January 2012 and December 2014 were retrospectively analyzed. Results There were 3 men and 2 women, aged 48 to 71. 4 patients were mis-diagnosed in the early stage. One patient was misdiagnosed as having Green-Barre syndrome and multiple myeloma, 2 patients were diagnosed as having numbness with unknown causes, 1 patient was misdiagnosed as having Castleman disease. All the patients underwent bone marrow examination, serum protein electrophoresis and immunofixation electrophoresis and their diag-nosis was confirmed after multidisciplinary consultations. Peripheral nerve injury improved in two patients after chemotherapy. The other three patients received Vitamin treatment but peripheral nerve injury did not improve and then the patient was dis-charged from hospital and lost in follow-up. Conclusion POEMS syndrome is a multisystemic disorder syndrome. When a patient presents polyneuropathy with multisystemic disorder, we should conduct a comprehensive assessment to reduce the mis-diagnosis and mistreatment rates.%目的 探讨POEMS综合征的诊治要点,以提高对该病的认识.方法 对我院2012年1月—2014年12月收治临床诊断为POEMS综合征5例的临床资料进行回顾性分析.结果 5例中男3例,女2例;年龄48~71岁.4例在疾病早期误诊,2例初诊为肢体麻木原因待查,1例先后误诊为格林-巴利综合征和多发性骨髓瘤,1例误诊为Castleman病.所有患者入院后均接受骨髓检查、血清蛋白电泳及免疫固定电泳检查并经多科会诊确诊为POEMS综合征.2例进行化疗,周围神经损害症状好转后回当地医院治疗;3例拒绝化疗仅予营养神经治疗,周围神经损害无好转,后出院失访.结论 POEMS综合征临床表现多样,接诊多发性神经病变并多系统损害患者应考虑到该病可能,应对其进行全面评估,以减少或避免误诊误治.
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