Objective To observe clinical effects of Alprostadil combined with hyperbaric oxygen in treatment of sudden deafness.Methods A total of 142 patients with sudden deafness admitted during September 2014 and September 2016 were divided into observation group and control group (n=71 for each group) by sortition method.All patients were treated with Mecobalamin, Extract of Ginkgo Biloba Leaves Injection and hyperbaric oxygen.On the basis treatment, observation group was treated with Alprostadil, while control group was treated with Dexamethasone.Clinical efficacy, results of sound heating threshold test and hemorrheologic changes were compared between the two groups.Results Compared with those before treatment, in the same group after treatment, the 0.5 kHz, 1 kHz, 2 kHz and 4 kHz of air conduction hearing threshold values, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and fibrinogen levels were decreased in two groups (P<0.05);compared with those in control group, the decreased degrees in above indexes were more obvious in observation group (P<0.05).The total effective rate in observation group (90.1％) was significantly higher than 77.5％ in control group (P<0.05).Conclusion Alprostadil combined with hyperbaric oxygen may decrease blood viscosity, promote local blood circulation, relieve microcirculation disturbance of inner ear and improve hearing level of patients with sudden deafness.%目的 观察前列地尔联合高压氧治疗突发性耳聋的临床效果.方法 选取我院2014年9月-2016年9月收治的142例突发性耳聋,按照抽签法随机分为观察组与对照组,每组各71例.两组均予甲钴胺、银杏叶提取物注射液及高压氧治疗,在此基础上,观察组予前列地尔治疗,对照组予地塞米松治疗.比较两组临床疗效、纯音听阈测试结果及血液流变学变化.结果 与本组治疗前比较,两组治疗后0.5 kHz、1 kHz、2 kHz、4 kHz气导听力阈值、全血高切黏度、全血低切黏度、血浆黏度及纤维蛋白原水平均降低,差异均有统计学意义(P<0.05);与对照组比较,观察组上述指标降低更为显著,差异均有统计学意义(P<0.05).观察组治疗总有效率(90.1％)显著高于对照组(77.5％),差异有统计学意义(P<0.05).结论 前列地尔联合高压氧治疗突发性耳聋可降低血液黏稠度,促进局部血液循环,改善内耳微循环障碍,提高听力水平.
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