口腔癌患者外周血细胞免疫水平与临床结局的相关性分析

摘要

Objective To investigate correlation between immune cell levels of peripheral blood and clinical outcomes in patients with month cancer.Methods A total of 50 patients with month cancer admitted during January 2014 and January 2015 were selected as month cancer group,and 50 healthy people taking medical examination were chosen as control group.Levels of peripheral blood lymphocytes (CD3+,CD4+,CD8+ and CD19+) and natural killer (NK) cells were compared,and correlations between levels of peripheral blood lymphocytes (CD3+,CD4+,CD8+ and CD19+) and NK cell and clinical characteristics were analyzed in two groups.Results Compared with those in control group,levels of CD3+ and CD4+ T lymphocyte,CD4+/CD8+ and NK lymphocyte were significantly decreased (P0.05).Compared with those in patients with stage Ⅲ-IV,levels of CD3+,CD4+ and CD8+ T lymphocyte,CD4+/CD8+ and NK lymphocyte were significantly increased (P0.05).Compared with those in patients without recurrence,levels of CD3+ CD4+ and CD8+ T lymphocyte,CD4+/CD8+ and NK lymphocyte were significantly decreased (P0.05).与Ⅲ~Ⅳ期口腔癌患者比较,Ⅰ~Ⅱ期患者的CD3+、CD4+及CD8+T淋巴细胞、CD4+/CD8+和NK细胞显著升高(P0.05).与无复发患者比较,术后复发者CD3+、CD4+及CD8+T淋巴细胞、CD4+/CD8+和NK细胞显著降低(P<0.05),CD19+T淋巴细胞显著升高(P=0.000).结论 口腔癌患者存在一定程度的免疫抑制,且外周血细胞免疫水平与其预后密切相关.