Objective To investigate clinical effect of Yinxie capsule combined with Acitretin in treatment of patients with psoriasis vulgaris and its effect on immune function of T lymphocytes in peripheral blood. Methods A total of 88 patients with psoriasis vulgaris,who had met in the admittance and exclusion criteria,were divided into control group (n=44) and observation group (n=44) by random number method. Observation group was treated with Yinxie capsule combined with Acitretin,while control group was treated with Acitretin. Psoriasis area and sever-ity index (PASI) scores and T lymphocyte subsets in peripheral blood before and in 8 weeks after treatment,clinical efficacy in 8 weeks after treatment and incidence conditions of adverse reactions during course of treatment were ob-served and compared in two groups. Results There were no significant differences in PASI scores and T cell sub-sets in peripheral blood before treatment in two groups (P>0.05). In 8 weeks after treatment, PASI scores and CD8+ were significantly lower,while CD3+,CD4+ and CD4+/CD8+ levels were significantly higher than those before treatment in two groups(P0.05).治疗8周后,两组PASI 和CD8 +均较治疗前降低,CD3 +、CD4 +及CD4+/CD8+均较治疗前升高,差异具有统计学意义(P<0.05).治疗8周后,观察组PASI和CD8+低于对照组, CD3+、CD4+及CD4+/CD8+高于对照组,差异具有统计学意义(P<0.05).治疗8周后,观察组总有效率为93.18%,对照组总有效率为72.27%,观察组明显高于对照组,差异具有统计学意义(P<0.05).治疗过程中观察组出现恶心1例;对照组出现头痛1例,恶心2例.结论 银屑胶囊联合阿维A治疗寻常型银屑病临床效果显著,可能通过改变外周血T淋巴细胞免疫功能失衡状态而发挥相关作用.
展开▼
