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Construction and characterization of UAA-controlled recombinant Zika virus by genetic code expansion

         

摘要

Dear Editor,Genetic code expansion based on orthogonal tRNA-aminoacyl tRNA synthetase is an emerging technology to sitespecifically incorporate unnatural amino acids(UAAs)into viral proteins to produce UAA-controlled replication-defective virus.

著录项

  • 来源
    《中国科学》 |2021年第1期|P.171-173|共3页
  • 作者单位

    Graduate School Anhui Medical University Hefei 230032 ChinaDepartment of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

    Department of Chemical Biology State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China;

    Graduate School Anhui Medical University Hefei 230032 ChinaDepartment of Virology State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 有机化学;
  • 关键词

    expansion; characterization; incorporate;

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