B7S1, a novel candidate for anti-tumor checkpoint blockade immunotherapy

摘要

Antigen-specific CD8+T cells play a critical role in eradicating transformed or virally infected cells. Upon recognition of cancerous or viral originated peptides, presented by antigen-presenting cells (APCs) in the form of peptide-MHC class I complex, CD8+T cells become activated, rapidly and extensively proliferate and differentiate into functionally competent effector cells. Following successfully and timely clearing transformed or virally infected cells, the majority of effector CD8+Tcells die of apoptosis. Concomitantly a small fraction (around 5%–10%) of effector CD8+T cells survive and progressively differentiate into long-lived and self-renewable memory CD8+T cells. When reencountering