AIM To study the glucose and lipids metabolis m and insulin sensitivity of MSG rats during their growing period, and to evalua te the effects of insulin sensitizer pioglitazone on the model rats. MET HODS Body weights were measured regularly, and glucose and insulin tole rance tests were taken. In their 3 and 10 months old, rats were given insulin se nsitizer pioglitazone orally, then the effects on serum glucose, triglyceride, c holesteral, free fatty acid and insulin concentrations were determined. RESULTS Compared with normal rats, a slight but significant increase of glucose in MSG rats was revealed. The serum triglyceride, cholesteral, free fat ty acid and insulin concentrations were significantly higher in model rats. More over, gluconeogenesis increased significantly, and insulin tolerance showed abno rmal. However, glucose tolerance was nearlly normal. Pioglitazone could ameliora te all these metabolic disorders. CONCLUSION Obesity and insuli n resistance were induced by injecting monosodium glutamate (MSG) to neonatal Wi star rats. Pioglitazone can significantly improve the insulin sensitivity of MSG rats. These results suggested that MSG obese rats can be used as an easily acce ssible and inexpensive insulin resistance animal model for evaluating the effica cy and mechanisms of antidiabetic agents.%目的观察MSG大鼠发育生长过程中糖脂代谢以及对胰岛素敏感性的变化，并研究胰岛素增敏剂吡咯列酮（pioglitazone）的作用。方法建立MSG大鼠模型。3 mon及10 mon 时，分别给药吡咯列酮，观察药物对MSG大鼠血糖、甘油三酯、总胆固醇、游离脂肪酸、血胰岛素以及葡萄糖耐量、胰岛素耐量、糖异生等的影响。结果和正常对照组相比，MSG大鼠表现为血糖略有升高，血脂及血胰岛素升高，具糖耐量异常趋势，胰岛素耐量异常，糖异生增加，给药后均有改善。结论 MSG大鼠可能由于肥胖导致脂质代谢异常，从而影响胰岛素敏感性，造成严重的胰岛素抵抗。胰岛素增敏剂吡格列酮可明显改善这种代谢异常。提示MSG肥胖大鼠可作为一种较经济简便的胰岛素抵抗动物模型，用于药物评价以及作用机制研究。
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