Prediabetes and type 2 diabetes implication in central proliferation and neurogenesis

摘要

Type 2 diabetes(T2D)is an important risk factor for developing dementias,including Alzheimer’s disease(AD).Hyperinsulinemia and glucose intolerance,as features of T2D,might increase the neurodegeneration process,synaptic loss and brain atrophy,leading to cognitive impairment observed in AD.Also,adult neurogenesis seems to be impaired in AD models.Therefore,we have studied morphological alterations,cell