反复自然流产患者TORCH感染与细胞因子水平的变化

摘要

目的研究反复流产患者弓形虫、巨细胞病毒、风疹病毒、单纯疱疹病毒(TORCH)感染与TNF、IL-6含量的关系；探讨反复流产患者的发生机理。方法采用酶联免疫吸附法检测56例流产患者、20例早孕妇女及20例非孕妇女血清中TORCH-IgM、TNF、IL-6的水平。结果流产组TORCH感染率和TNF、IL-6的含量明显高于正常对照组(P＜0.05)，多种病原体感染患者TNF、IL-6含量升高明显，TNF、IL-6水平在正常早孕妇女及非孕妇女组无显著性差异(P＜0.05)。结论反复流产与TORCH感染有关，两种或两种以上病原体感染可能存在着病毒间的相互作用，加重流产的发生；TNF、IL-6含量变化对反复流产的发生发展及生殖具有重要的病理生理学意义。%Aim In order to know the relationship in Toxoplasma gondii, Rubella virus, Cytomegalo virus, Herpes simplex virus(TORCH) infection with cytokine level and immunologic mechaism in recurrent spontaneous abortion woman. Methods TORCH-IgM,TNF,IL-6 in 56 cases of recurrent spontaneous abortion, 20 cases of early pregnant and 20 cases of nonpregnant women were determind by ELISA. Results The infection rates TORCH and TNF,IL-6 levels of the abortion group were significantly elevated compared with the corresponding levels of controls (P＜0. 05). Level of TNF,IL-6 were higher in various kind of pathogen infection. But level of TNF,IL-6 were no difference between normal early pregnant and nonpregnant women (P ＞ 0. 05). Conclusions In view of the proven fingdings that TORCH infection were important pathogens leading to recurrent spontaneous abortion. possibly, there is relationship between them in two or over two kinds of pathogen infection. TNF,IL-6 do have detrimental effects on proliferation, embry development and fetal survival.