目的 了解郑州市感染性腹泻病人中沙门病原菌血清型分布和耐药谱,为沙门菌防治提供基础数据.方法 从2006-2011年腹泻病监测点感染性腹泻病例的粪便标本中进行沙门菌分离培养、血清学分型及药敏试验,用WHONET5.4软件分析药敏试验结果.结果 2006-2011年共采集的3 266份腹泻病人标本中共检出196株沙门菌,检出率为6.0%,分布于10个血清群,37个血清型;以B群和D1群为主,各占33.67%(66/196)和32.14%(63/196);血清型以肠炎沙门菌和鼠伤寒沙门菌为主,各占29.59%(58株)和19.90%(39株).药敏试验结果提示对氨苄西林、萘啶酸、复方新诺明和四环素的耐药率分别达到44.90%、42.34%、34.18%和32.14%.结论 沙门菌血清型和耐药谱监测对感染性腹泻疫情防控意义重大.%The objective of the present study is to understand the serotype distribution and antibiotic resistance of Sal monella spp. in infectious diarrhea cases, and to provide the scientific basis for diseases control and treatment. Salmonella strains were isolated from infectious diarrhea cases and tested for serotyping and antibiotic sensitivity during 2006-2011. Re suits were analyzed by WHONET 5. 4 software, and all 196 isolates of Salmonella were detected from 3 266 diarrhea patients and distributed in 10 serogroups and 37 serotypes. The detection rate was 6. 0% and there were about 66 isolates belong to se rogroup B (33. 67%) and 63 belong to serogroup Dl (32. 14%). The main serotypes were Salmonella enteritis and Salmonella typhimurium (29.59%, 58/196; 19.90%, 39/196). Antibiotic sensitivity tests showed the isolates were resistant to nalidixic acid, ampicillin, tetracycline, andSXT, and the resistance rates were 42. 34% , 44.90%, 32.14%, and 34. 18%, respective ly. It's suggested that there is significant to monitor the serotypes and antibiotic resistance of Salmonella spp. infection for pre vention and control of epidemic diarrhea.
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