Synthesis, Crystal Structure and Anti-breast Cancer Activity of ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-Methylbenzenesulfonate

摘要

The new heterocycle compound ((3 S,5R)-5-((1 H-1,2,4-triazol-l-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1),designed using ((3R,5S)-5-(2,4-difluorophenyl)-5-iodotetrahydrofuran-3-yl)methyl isobutyrate (2) as the start material,was successfully obtained via multiple synthesis route and finally characterized by IR,1H NMR,and single-crystal X-ray crystallography.In addition,the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against three human breast cancer cell lines BT474,MCF7 and MB.