Syntheses, Crystal Structures and Antitumor Activities of Two Nicotinamides

摘要

Two nicotinamides have been synthesized by coupling aromatic amines with equimolar quantities of substituted nicotinic acids. Their structures have been determined by X-ray single-crystal diffraction. Compound 1, 6-chloro-N-(4-fluorophenyl)nicotinamide, crystallizes in the triclinic space group Pī with a = 4.2188(8) , b = 5.0687(10), c = 25.956(5), α = 86.38(3), β = 87.75(3), γ = 83.20(3)°, V = 549.75(19) 3 and Z = 2. Compound 2, N-(quinolin-3-yl)nico- tinamide, crystallizes in the monoclinic space group P21 with a = 8.5100(17), b = 6.4230(13), c = 11.620(2) , β = 110.39(3)°, V = 595.3(2) 3 and Z = 2. The cytotoxic activities of the two nicotinamides against five human tumor cell lines were tested in vitro. The results indicated that they showed a wide range of antitumor activities.