Synthesis, Characterization and Theoretical Studies of a Novel Salt (Dexmedetomidine: Perchloric Acid =1∶1) and the Investigation of Its Stability

摘要

Dexmedetomidine and its novel salt have been synthesized and characterized by single-crystal XRD and TGA/DSG.Components of the crystalline phase have also been investigated in terms of their corresponding Hirshfeld surface.In the crystal lattice,a three-dimensional hydrogen-bonded network is observed.In this work,the salt strategy has been applied successfully to dexmedetomidine.One important parameter,i.e.stability,has also been significantly improved,which proves to be an important factor for solid dosage formulation.Furthermore,DSC/TGA analysis indicates that the salt maintains its crystallinity up to 300 ℃,suggesting a higher stability of the salt compared to pure dexmedetomidine.