Synthesis, Crystal Structure and Cytotoxic Activities of Oxazolidin-2-one Derivatives

摘要

Four cytotoxic oxazolidin-2-one derivatives were prepared from alkynyl alcohol and isocynate with high yields of 83 ～95％,and their structures were characterized by IR,H-RESI-MS and NMR analysis.Meanwhile,the crystal of (Z)-4-benzylidene-3-ethyl-l-oxa-3-azaspiro[4.4] nonan-2-one (5a) was obtained and determined by X-ray single-crystal diffraction.Crystal data:monoclinic system,space group P121/cl,a =10.9284(2),b =9.47510(10),c =14.2510(2) (A),β =111.917(2)°,V=1369.01(3)(A)3,Z =4,F(000) =552.0,Dc =1.248 Mg/m3,μ =0.652 mm-1,R =0.0473 and wR =0.1207 for 2699 independent reflections (Rint =0.0206) and 2581 observed ones (I ＞ 2σ(I)).