目的 探讨肝气郁结证在特定脑区功能的改变.方法10只Wista大鼠采用慢性应激结合孤养方法制备肝气郁结证大鼠模型,分别于造模前后进行氟18脱氧葡萄糖(18F-FDG)PET正电子扫描,应用SPM2图像分析软件对造模前、造模后数据进行双样本t检验.结果葡萄糖代谢减低脑区(P＜0.001)有左侧额叶、顶叶、下丘脑,双侧后扣带回,右侧前扣带回.葡萄糖代谢升高脑区(P＜0.001)有左侧海马旁回、岛叶、颞叶、额叶,右侧基底核、丘脑.结论肝气郁结证可引起特定脑区的功能改变.%Objective To explore the characteristics of brain function in rats with Stagnation of Liver-qi Syndrome. Methods Model of Stagnation of Liver-qi was made with chronic stress combined with isolated raising in 10 normal Wistar rats. They were scanned with positron emission tomography (PET) before and after modeling. Data analysis was carried out using SPM (statistical parametric mapping 2) in MATLAB software. Results After modeling, the glucose metabolism decreased (P<0.001) in left frontal lobe, parietal lobe, hypothalamus; bilateral posterior cingulate; right anterior cingulate, while the glucose metabolism increased (P<0.001) in left parahippocampal gyrus, insu-la, temporal lobe, frontal lobe; right basal ganglia, thalamus. Conclusion The function of some cerebral areas can be changed undergoing Stagnation of Liver-qi Syndrome.
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