Objective To assess intra-and inter-scanner test-retest reliability in 3D whole-brain pseudo-continu⁃ous arterial spin labeling (pCASL) of the auditory cortex in healthy adults. Methods Eight healthy subjects were scanned three times on two 3.0T MR scanners with 3D whole-brain pCASL technique. The 1st and 3rd tests were done on Scanner 1 and the 2nd test on Scanner 2. Intervals between tests were 10~15 days. Two sets of ASL data with post labeling delay time (PLD) at 1.5 or 2.5 seconds were acquired during each test. Volumetric T1-weighted images of the whole brain were also ac⁃quired for image registration. Cerebral blood flow (CBF) values of the auditory cortex were extracted for comparison. The in⁃tra-and inter-scanner test-retest reliability was evaluated with the intraclass correlation coefficient (ICC) and Bland-Alt⁃man plots. Results Overall, the auditory cortex CBF value was 51~61 ml/min/100g for PLD=1.5s and 43~54 ml/min/100g for PLD=2.5s. For PLD=1.5s, the ICC was 0.50 for comparison between the 1st and 2nd tests, 0.83 for comparison between the 2nd and 3rd tests, and 0.85 for comparison between the 1st and 3rd tests. For PLD=2.5s, the ICC was 0.76 for comparison be⁃tween the 1st and 2nd tests, 0.89 for comparison between the 2nd and 3rd tests and 0.88 for comparison between the 1st and 3rd tests. Bland-Altman plots indicated better reproducibility for PLD=2.5s than for PLD=1.5s. Conclusions The 3D whole-brain pCASL technique can be used for measuring CBF in the auditory cortex with high test-retest reliability, which indicates its value in MR research on blood flow of the auditory cortex across multiple centers.% 目的研究正常成人听皮层磁共振三维动脉自旋标记灌注成像(three dimensional arterial spin labeling,3D ASL)技术的可重复性.方法8例健康成年人在2台同一机型的3.0T磁共振扫描仪上进行了3次全脑3D ASL序列扫描,在1号扫描仪上进行第1次和第3次扫描,在2号扫描仪上进行第2次扫描,三次扫描间隔时间均为10~15天.每次扫描两次3D ASL序列,标记延迟时间(post labeling delay time, PLD)分别选择1.5s和2.5s.对3D结构像进行听皮层结构分割,计算脑血流(cerebral blood flow, CBF)图,并提取听皮层CBF值.对于3次测量结果采用组内相关系数(intraclass correlation coefficient, ICC)及Bland-Altman法进行统计分析.结果听皮层CBF值在51~61 ml/min/100g(PLD=1.5s)和43~54 ml/min/100g之间(PLD=2.5s).第1次与第2次扫描结果比较,PLD为1.5s时ICC值为0.50,PLD为2.5s时为0.76；第2次与第3次扫描结果比较,PLD为1.5s时ICC值为0.83,PLD为2.5s时为0.89；第1次与第3次扫描结果比较,PLD为1.5s时ICC值为0.85,PLD为2.5s时为0.88.Bland-Altman图显示PLD为2.5s数据的分布范围比PLD为1.5s有明显的缩小.结论3D-ASL序列可以进行听皮层CBF值测量,PLD较长时测量的可重复性较好,可用于听皮层血流灌注的多中心研究.
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