目的：通过对梅尼埃病(Meniere disease，MD)患者眼肌前庭诱发肌源性电位(ocular vestibular-evoked myogen⁃ic potential，oVEMP)结果进行分析，进一步探讨梅尼埃病患者oVEMP的临床特征。方法对66例梅尼埃病患者及27例年龄、性别与之匹配的健康人进行oVEMP测试,分析对比oVEMP的引出率及各参数指标。结果oVEMP在病例组患侧的引出率为41.7%、健侧为55%,对照组为100%；患侧与健侧比较差异无统计学意义(P>0.05),患侧、健侧与对照组比较差异均有统计学意义(P<0.05)。病例组患侧、健侧及对照组间oVEMP的振幅及不对称比均有统计学差异(P＜0.05)，然各波潜伏期相比无统计学意义。整体来讲，梅尼埃病患者oVEMP引出率随听力学分期升高而呈逐渐下降趋势。结论梅尼埃病患者无论健侧还是患侧,其oVEMP异常均较显著,且以患侧变化显著,提示MD患者的椭圆囊功能受损， oVEMP可用于评估MD患者椭圆囊功能，且进一步对其诊疗作出指导。%Objectives To report ocular vestibular evoked myogenic potential (oVEMP) results in a group of patients with Meniere's disease. Methods We enrolled 66 patients with Meniere's disease as the observation group and 27 (54 ears) age-and gender-matched normal subjects as the control group. Both patients and normal subjects underwent conventional oVEMP tests in bilateral ears. The results of the affected ears were compared with the contralateral ears and with the normal controls. Results oVEMPs were elicited in 30 affected ears (41.7%), 33 contralateral ears (55.0%) and all normal ears (100.0%). Difference in response rate was not found between the affected ears and the contralateral ears (P>0.05 ), but be-tween both affected ears and contralateral ears in patients and the normal controls (P<0.05). There were differences in the amplitude and asymmetry ratio among the affected ears, contralateral ears and control ears (P<0.05), but not in the latency. Overall, in patients with Meniere's disease, the rate of successful oVEMPs induction decreased as hearing grades worsened. Conclusion The rate of oVEMP responses in patients with Meniere’s disease (in both the affected and contralateral ears, but especially in the affected ear) is significantly lower than in normal subjects, suggesting damage to utricular functions in these patients. oVEMP examination can be used to evaluate utricular functions in Meniere’s disease, and guide diagnosis and treatment.
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