Objective: We used those solid phase grinding, heating precipitation and homogeneous precipitation, several methods to prepare the superparamagnetic nanoparticles (γ- Fe2O3)for drug embedded, and compared the preparation methods with time, particle size, purity. Methods: We used FeCl3- 6H2O,FeCl2-4H2O NNaOHNFe (NO3)3- 9H2O and so on as material, respectively, to prepare superparamagnetic nanoparticles by solid-phase ginding, chemical precipitation and homogeneous precipitation, and observed the particle size by scanning electron microscopy. Results; Solid-phase grinding may cause the particle lattice distortion and serious reunion. Derived from chemical precipitation particle the size is good, affected by many factors. The homogeneous precipitation method can be adjusted nanoparticle formation rate and the shape is spindle. Conclusions: The chemical precipitation method is simple for laboratory to prepare superparamagnetic nanoparticles (γ- Fe2O3).%目的:通过固相研磨、化学加热沉淀以及均匀沉淀三种不同方法制备纳米氧化铁粒子Fe2O3,从中选择具有超顺磁性特质的纳米粒子晶型,为药物包被做前期准备,并对制备方法从制备时间、粒子粒度以及纯度等方面进行比较.方法:利用化学分析纯级别的FeCl3·6H2O、FeCl2·4H2O、NaOH、Fe (NO3)3·9H2O等作为初始原料,分别采用固相研磨法、化学沉淀法以及均匀沉淀法制备出磁性纳米粒子,利用XRD衍射比较粒子晶型,选出超顺磁性纳米粒子(γ-Fe2O3),并通过扫描电子显微镜观察粒径等特质.结果:固相研磨法可能会使粒子晶格畸变、团聚现象严重,化学加热沉淀法所得粒子粒径好、但是受影响因素较多,均匀沉淀法可以调节纳米粒子核形成速率、粒径大小可以控制.结论:通过比较分析,化学沉淀法操作简单适合于实验室制备实验用超顺磁性纳米粒子(γ-Fe2O3).
展开▼
