In vivo simultaneous monitoring of blood flow and changes of concentration of oxyhemoglobin (ΔHbO2) in brain is a key important method for the research of cerebrovascular disease. In this study, a new monitoring system, combining laser speckle contrast imaging method and spectral analysis method, was proposed, which could be utilized to measure the cerebral blood flow and ΔHbO2 on mice during traumatic brain injury. The principle of the present system was studied and the hardware platform of the detection system was built. Then, user interface software and algorithms were implemented based on Labview and Matlab software. Finally, the performance of the present system was verified by the in vivo experiments.%同时在体测量脑血流及脑氧合血红蛋白变化量(ΔHbO2)是研究脑神经血管疾病的重要方法. 该文利用激光散斑衬比成像技术和光谱分析方法,搭建了一套能够在小鼠颅脑损伤过程中同时测量脑血流和ΔHbO2的监测系统.该文介绍了系统的基本原理,构建了基于Labview和Matlab开发环境的上位机软件,该软件实现了激光散斑原始数据和光谱数据的采集和处理.最后通过实验验证了系统的性能和有效性.
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