一种模拟心脏血流形态的药物洗脱支架的药物释放装置

摘要

该文介绍了一种新型模拟心脏血流形态的药物释放装置，利用该装置来模拟人体生理环境下药物洗脱支架中药物的释放。实验结果表明，该装置测定释放度的结果满足试验规律，具有一定的体内外相关性，从而说明本装置具备作为体外释放度测定方法的价值。%A novel drug delivery device simulating the cardiovascular bloodfl ow pattern was introduced. The device was used to simulate the in vivo drug release in the drug-eluting stents. The results regarding the drug release rate were subject to the pattern from in vivo measurement. Therefore, the device was validated as a measurement method for in vivo drug release rate.