Objective To investigate the distribution and drug-resistance of Burkholderia cepacia isolated from an intensive care unit (ICU) in a hospital. Methods Burkholderia cepacia isolated from ICU in a hospital between January 2008 and December 2009 were analysed retrospectively. Results 166 strains of Burkholderia cepacia were isolated, which accounting for 23. 82％ (166/697) of the total isolated strain, 153 of which were isolated from sputum and throat swabs, 9 from urine, 2 from fluid in blood catheter,2 from drainage fluid. Antimicrobial susceptibility test showed that Burkholderia cepacia had high resistance to antimicrobial agents including cefazolin, imipenem,ampicillin/sulbactam, gentamicin, tobramycin, and amikacin, which were up to 98. 19％ - 100. 00％; and Burkholderia cepacia had low resistant rate (11.45％) to the third-generation cephalosporins (ceftazidime). The lowest resistant rate (10. 84％) was to piperacillin/tazobactam. Conclusion The isolation of Burkholderia cepacia is high in ICU in this hospital, and resistance to commonly used antimicrobial agents is high, clinicians should perform pathogenic detection, and use antimicrobial agents rationally.%目的 调查某院重症监护室(ICU)洋葱伯克霍尔德菌的分离及耐药情况.方法 回顾性分析该院ICU2008年1月-2009年12月检出的洋葱伯克霍尔德菌资料.结果 调查期间ICU送检的各类标本共分离洋葱伯克霍尔德菌166株,占总检出菌株数的23.82%(166/697);其中痰和咽拭子分离153株,中段尿9株,血管导管液2株,引流液2株.药敏结果显示,洋葱伯克霍尔德菌对头孢唑林、亚胺培南、氨苄西林/舒巴坦、庆大霉素、妥布霉素、阿米卡星耐药率高,达98.19%～100.00%;对第三代头孢菌素(头孢他啶)的耐药率较低(11.45%),对哌拉西林/他唑巴坦的耐药率最低(10.84%).结论 洋葱伯克霍尔德菌在该院ICU分离率较高,对临床常用的抗菌药物有极高的耐药性,临床医生应积极开展病原学检查,注意正确、合理使用抗菌药物.
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