HTR1A is a kind of receptor subtypes to express the most 5-HT in the brain of mammalian. Genetic variation in the gene through influencing the expression of receptors or changing the activity of the ligand binding to increase or decrease the function of 5-HT, so it played a key role in the pathogenesis of depression and other mental system diseases. The article reviewed the association between the genetic mutations of HTR1A and the corresponding mental system disease. Research the relationship of HTR1A gene and mood changes such as depression, panic, impulsive personality and its significance in forensic judicial authentication. To explore the causes of criminal mode from the perspective of gene - psychology - social model.%五羟色胺受体1A基因的遗传变异通过影响受体的表达量或与配体结合的活性变化而增强或减弱5-HT的功能,在抑郁症及部分精神系统疾病的发病机制中起着重要的作用.文章通过对HTR1A基因遗传学多态性与部分精神系统疾病的关系进行综述.研究HTR1A基因与抑郁、恐慌、冲动易怒等情绪变化在法医司法精神病鉴定中的意义,并从基因-心理-社会模型的角度探讨犯罪行为的成因.
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