STR基因座单倍型的推断方法初探

摘要

Referring to the statistical model for the SNP haplotype phasing which was based on the allele frequencies and advised by Browning SR, we investigated and deduced the phasing method of STR haplotype with linkage disequilibrium inpaternity testing preliminarily. Haplotype phasing of two X-STRs in linkage disequilibrium were illustrated. This method provides an idea for the haplotype phasing of STR markers, which is helpful for interpreting the typing results of STR more scientifically and accurately.%本文参考Browning SR等提出的以SNP等位基因频率为基础,通过统计学模型推断SNP单倍型的方法,初步探讨亲权鉴定中STR基因座单倍型的推断方法.以两个处于连锁不平衡状态的X-STR基因座的女性分型结果为例进行说明.本方法为STR单倍型的推断提供了一个思路,有助于更科学准确地进行STR分型结果的解释.