系统性红斑狼疮患者医源性感染与致病菌耐药性的研究

摘要

Objective To study the percentage and the distribution of nosocomial infection, and susceptibility of related pathogens to antibiotics in patients with systemic lupus erythematosus (SLE). Methods The clinical data of in-patients with SLE in our hospital from June, 1990 to June, 1998 were analyzed. The susceptibility of the pathogens to antimicrobial agents was tested by K - B paper dilution method. Results The percentage of nosocomial infection in these cases was 16. 1%. The major pathogens were staphylococcas aureus, Escherichia coli and Candida. The most highly resistant microbes were E. coli, S. arueus and Pseudomonas aeruginosa. Conclusions The nosocomial infection is one of the most common complication of SLE in the in-patients. It is necessary to examine the pathogens regularly and use antibacterial agents according to the susceptibility.%目的探讨系统性红斑狼疮(SLE)患者医院感染率、病原菌的分布特征及致病细菌耐药情况。方法回顾性分析我院近8年收治的SLE患者医院感染情况，用K-B纸片扩散法对致病菌进行抗生素敏感性测定。结果 SLE患者医院感染率为16.1％，致病菌主要是金黄色葡萄球菌、大肠杆菌及念珠菌属；高耐药菌种有大肠杆菌、金黄色葡萄球菌、绿脓杆菌等。结论医源性感染是SLE的常见并发症及死亡的重要原因，应定期进行病原学监测，依据药物敏感性选择抗生素。