钙拮抗剂对牙龈成纤维细胞作用的体外实验研究

摘要

AIM: To investigate the effects of nifedipine, a calcium channelblocker, on cellular proliferation of gingival fibroblasts in vitro. METHODS: Gingival fibroblasts were cultured and incubated with various concentrations of nifedipine(1?200, 360,108 and 23.5μg/L)for 7days. RESULTS: Cell numbers were different significantly among those groups on the sixth and seventh day, especially between 1?200μg/L(or 360μg/L) group and other groups. CONCLUSIONS: Nifedipine can influence the proliferation of gingival fibroblsts at high concentration.%目的：探讨钙拮抗剂硝苯地平对牙龈成纤维细胞的作用。方法：体外培养牙龈成纤维细胞，细胞在不同浓度硝苯地平作用下计数观察。结果：细胞计数在实验第6、7天出现组间非常显著性差异。主要表现为硝苯地平1?200μg/L和360μg/L组，细胞计数明显高于低剂量组。结论：高剂量硝苯地平有刺激牙龈成纤维细胞增殖的作用。