目的:评估无监督情况下家庭日常使用高露洁抗敏牙膏4周后牙本质过敏症状的改善情况.方法:本研究为单一产品、单盲、多中心的I临床研究.采用数字化疼痛评判法(VAS)筛选受试者.通过普通牙膏洗脱2周去除干扰因素后,给予受试者高露洁抗敏牙膏和软毛牙刷,用VAS法分别于基线(VAS-1)和4周实验结束后(VAS-2)评估受试者牙本质敏感情况.结果:本研究共筛选1315人,纳入受试者210名,完成试验者193名,基线时VAS平均值为54.94±13.81;试验4周后VAS平均值为36.87±18.75,前后比较差异有统计学意义(P<0.001).结论:日常使用高露洁抗敏感牙膏4周,对牙本质敏感症有一定的改善作用.%AIM:To evaluate the effects of daily application of Colgate anti - sensitivity toothpaste on relie ving dentinal hypersensitivity. METHODS: The study was a single - blind multicentered clinical trial. Subjects, who were included by Visual Analog Scale (VAS) , undertook a washout period for 2 weeks by using Colgate non - sensitive toothpaste in order to eliminate interference factors. Then Colgate anti - sensitivity toothpaste and soft toothbrush were applied daily in next four weeks. The conditions of dentinal hypersensitivity were assessed by VAS at baseline and after 4 weeks. RESULTS;In total of 1315 individuals, 210 subjects participated and 193 were enrolled in the study. At the baseline, average VAS was 54.94 ± 13. 81; four weeks later, average VAS decreased to 36. 87 ± 18. 75. There was significant difference (P<0.001). CONCLUSION; Colgate anti -sensitivity toothpaste can relieve dentinal hyper sensitivity.
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