牙周基础治疗对Ⅱ型糖尿病伴牙周炎病人糖基化终产物的影响

摘要

目的:观察牙周基础治疗对Ⅱ型糖尿病伴慢性牙周炎病人牙周组织和血清中糖基化终产物(advanced glycation end of products,AGEs)变化的长期影响.方法:诊断为Ⅱ型糖尿病并伴有中等程度以上牙周炎的病人30例,分为进行牙周基础治疗的干预组15例(DM1组),未进行牙周基础治疗的未干预组15例(DM2组);分别在初诊和每次复诊治疗前记录2组的探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)、空腹血糖、AGEs指标.结果:经牙周基础治疗后,DM1组牙周临床指标均有明显改善;2组AGEs水平有不同程度升高(P<0.05);DM1组第21个月AGEs水平显著低于DM2组,有统计学意义(P<0.05).结论:牙周基础治疗对Ⅱ型糖尿病伴慢性牙周炎病人的PD、AL、血糖水平、AGEs水平有显著的改善(P<0.05),并且有助于长期稳定.%AIM : To observe the effect of periodontal initial therapy on the changes of advanced glycation end products ( AGEs) and periodontal status in type 2 diabetes mellitus patients with periodontitis.METHODS : Thirty type 2 diabetes patients with periodontitis were enrolled in this study.The patients were divided into two groups with 15 subjects in each group: DMI group with periodontal therapy and DM2 group with no periodontal intervention.Periodontal probing depth ( PD) , clinical attachment loss ( AI.) , serum glucose level and AGFs were recorded from first visit to twenty-first month.RESULTS: After periodontal initial therapy, all of periodontal clinical indexes in DMI group were significantly improved ( P ＜ 0.05 ).Both groups showed significandy elevated levels of AGEs ( P ＜ 0.05 ).The level of AGEs in DM1 group was significantly less than that of the DM2 group at month 21 (P ＜0.05).CONCLUSION: Periodontal initial therapy is effective to decrease the values of PD, AL and blood glucose and maintains their long-term stability.