糖尿病牙周炎病人颈动脉硬化相关因素分析

摘要

目的:探讨Ⅱ型糖尿病牙周炎病人与颈动脉硬化的关系.方法:随机选取20例健康对照组(A组),同期选取20例Ⅱ型糖尿病无合并症病人(B组),和20例Ⅱ型糖尿病仅合并牙周炎病人(C组).所有研究对象进行牙周检查,并测定身体质量指数(body mass index,BMI),空腹血糖(FPG),空腹胰岛素(FNS),游离脂肪酸(FFA)；免疫比浊法测定C反应蛋白(CRP).采用彩超测定所有研究对象的颈动脉内膜-中膜厚度(MT).结果:糖尿病组的FPG、FNS、FFA、CRP、MT水平均明显高于对照组.Pearson相关分析示:MT与FPG、FNS、FFA、CRP、BMI呈正相关；Logistic回归分析显示:MT与龈炎指数(GI)、临床附着丧失(CAL)、牙周袋探诊深度(PD)密切相关.结论:牙周炎与糖尿病并发颈动脉硬化有密切联系.%AIM; To investigate the relationship between periodontitis and carotid atherosclerosis in type 2rndiabetes patients. METHODS; Twenty healthy volunteers, 20 type 2 diabetes patients without complications and 20 type 2 diabetes patients with periodontitis were included in this study. Periodontal examination, body mass index (BMI) , fasting plasma glucose (FPG) , fasting insulin (FNS) , free fatty acid (FFA) , C-reactive protein (CRP) and carotid artery intiman-media thickness ( MT) were measured for each subject. Data were analyzed by Pearson correlation analysis and Logistic regression analysis with SPSS 15 software. RESULTS; FPG, FNS, FFA, CRP and MT levels in diabetic group were significantly higher than those in healthy volunteers. Furthermore, FPG, FNS, FFA, CRP and MT levels in periodontitis group were significantly higher than those in diabetic patients without periodontitis. MT was positively correlated with FPG, FNS, FFA, CRP and BMI by Pearson correlation analysis. Meanwhile, MT was closely related to GI, CAL and PD by Logistic regression analysis. CONCLUSION: Periodontitis is closely related with carotid atherosclerosis in type 2 diabetes patients.