One of the risk factors for bone loss in inflammatory bone diseases is the increase of bone-resor-bing osteoclasts. The cross-talk between osteoclasts and T/B cells plays an important role in physiological bone remodeling. Increasing activities of T cells and osteoclasts result in imbalance of bone remodeling. Notch signaling is a highly conserved cell signaling system, which controls the cell fate of T and B cells, as well as osteoclast differentiation. Further elucidation of Notch signaling mechanism in osteoimmunology will provide new targets at periodontitis. This review focusesl on the role of Notch in osteoimmunology and its potential effect on periodontitis.%破骨细胞是进行性骨吸收的主要功能细胞,其与T细胞、B细胞间的相互影响在生理性骨改建中发挥重要作用.免疫细胞活性异常和破骨细胞过度活跃是引发病理性骨改建(如发生在牙周炎中的牙槽骨吸收)的病理基础.Notch信号是一类种系发生高度保守的跨膜蛋白,不仅参与调控T细胞和B细胞的分化和功能,而且对骨改建中的主要功能细胞-破骨细胞的分化有重要的调控作用.因此,深入探讨Notch信号在骨免疫中的作用机制,可为牙周炎的临床治疗提供新的思路和依据.本文就Notch信号对骨免疫的调控机制及其在牙周炎发生中的可能作用作一综述.
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