AIM:To investigate the impact of ovariectomy on mandibular alveolar bone mineral density and periodontal disease.METHODS:Twenty 12-week-old female Wistar rats were randomly assigned into sham surgery (SHAM)group and ovariection(OVX)group (n=10).3 months after surgery,periodontal disease was induced by silk ligature around the neck of the mandibular right first molar for 2 months.Then the rats were sacrificed,Micro-CT scan was carried out to detect the bone mineral density (BMD),trabecular thickness (Tb.Th),bone volume fraction (BV/TV),trabecular separation (Tb.Sp.)and bone surface to bone volume (BS/BV)of mandibular alveolar bone. Alveolar bone height loss (ABHL)was measured on 3D models.RESULTS:5 months after ovariectomy,the values BMD,Tb.Th and BV/TV in OVX rats were lower than those in SHAMrats (P<0.05),whereas the values of Tb.Sp and BS/BV of the OVX rats increased compared with SHAM rats (P<0.05 ).However,no difference was found in ABHL between 2 groups.CONCLUSION:Ovariectomy induces osteoporosis in the mandibular alveolar bone of rats, but has no effect on the alveolar bone height loss of rats with experimental periodontitis.%目的：探讨切除卵巢后，大鼠牙槽骨骨质的变化情况及其对实验性牙周炎进展的影响。方法：取3月龄健康雌性Wistar大鼠20只，随机分为2组（n＝10），分别进行卵巢切除（卵巢切除组，OVX）和卵巢周围脂肪组织切除（假手术组，SHAM）；3个月后在所有大鼠下颌右侧第一磨牙（M1）牙颈部结扎丝线诱导牙周炎。于切除卵巢后第5个月处死各大鼠，显微CT测量骨形态学参数，并于三维重建模型上测量牙槽骨高度丧失程度。结果：术后5个月，OVX组大鼠牙槽骨的平均骨密度（BMD）、骨体积分数（BV／TV）、骨小梁厚度（Tb．Th）均明显低于SHAM组（P＜0．05）；骨表面积和体积比（BS／BV）、骨小梁分离度（Tb．Sp）均明显高于SHAM组（P＜0．05）；OVX组大鼠的牙槽骨高度丧失程度与SHAM组相比无明显差异（P＞0．05）。结论：大鼠去除卵巢后牙槽骨发生骨质疏松，但并不加重实验性牙周炎所致的牙槽骨高度丧失。
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