中医健脾单元疗法对强直性脊柱炎患者的疗效及对血清骨钙素、抗酒石酸酸性磷酸酶的影响

摘要

Objective To investigate and analyse clinical efficacy of Chinese medicine Spleen-strengthening therapy unit and its effect on serum bone gla protein(BGP) ,tartrate-resistant acid phosphatase (TRACP) .regulatory T cells(Treg) for Ankylosing Spondylitis( AS) patients. Method According to the random number table,60 cases of AS patients were divided into treatment group (34 cases) and control group(26cases). Treatment group adopted Chinese medicine Spleen-strengthening Therapy Unit, namely using Xinfeng capsule (XFC ) plus treatment based on traditional Chinese medicine syndrome(TCM) differentiation and traditional Chinese medicine fumigation treatment. The control group adopted sulfasalazine ( SASP) , with the rest equvilent to the treatment group treated. Using syndrome curative efficacy evaluating criteria of TCM to evaluate its clinical efficacy; Using enzyme-linked immunosorbent assay (ELISA) to determinate BGP,TRACP. Quality of life(QOL) ,symptoms and signs,acute phase reactants index and serum BGP,TRACP of the two groups were compared before and after treatment of AS patients. Result ( 1) Adopted by TCM efficacy evaluation, the total efficiency, significant efficiency-of the treatment group and the control group were 88.2% ,41.2% and 65.4% ,23.3% .which were differences statistically(P ＜0.05). (2) Serum BGP of AS patients after treatment in two groups was increased, while TRACP was decreased, with statistical significance ( P ＜ 0. 01) . Compared with the control group after treatment, serum BGP of the treatment group after treatment were significantly higher,TRACP was lower significantly( P ＜ 0. 01) . Conclusion Curative effect of Chinese medicine Spleen-strengthening therapy unit for AS patient is reliable and better than the control group, which can improve their quality of life and bone metabolism indexes.%目的 探讨中医健脾单元疗法对强直性脊柱炎(AS)患者疗效及对血清骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)的影响.方法 按随机数字表将60例强直性脊柱炎患者分成治疗组(34例)和对照组(26例),治疗组采用中医健脾单元疗法,即新风胶囊+中医辨证论治+中药熏蒸治疗,对照组采用柳氮磺嘧啶(SASP)+中医辨证论治+中药熏蒸治疗.结果 ①中医证候疗效评价结果示两组总有效率(65.4％比88.2％)差异有统计学意义(P＜0.05).②两组治疗后AS患者血清BGP水平升高,同时TRACP降低(P＜0.01),而治疗组治疗后血清BGP水平显著高于对照组,TRACP显著低于对照组(P＜0.01).结论 中医健脾单元疗法能够提高AS患者的生活质量,改善临床症状体征及骨代谢水平.