老年高血压患者脉压与微量白蛋白尿的关系

摘要

Objective To study the relationship between pulse pressure and urine microalbuminuria in aged patients with hypertension. Methods 131 elderly hypertesion patients with normal serum urea nitrogen ( Bun) , creati-nine (Cr)and 24h urine protein were divided into four groups by the level of pulse pressure (PP) ( <50 mmHg, 50-59 mmHg,60-69 mmHg, >70 mmHg). Urine albumin were determined by immunonephelometric methud. Results Among the four groups, the levels of UAER increased gradually with the PP levels (P < 0. 01). Conclusion PP is one of the high risk factors of renal damage in patients with hypertension.%目的 研究老年高血压患者脉压与微量白蛋白尿之间的关系.方法 将131例老年原发性高血压患者根据脉压水平分为4组(＜ 50 mm Hg,50～ 59 mm Hg,60 ～69 mm Hg,＞70 mm Hg),所有患者入选时血尿素氮、肌酐和24 h尿蛋白总量均在正常范围内.取晨尿用免疫散射法测定尿白蛋白含量,计算尿白蛋白排泄率(UAER).结果 25例脉压＜50 mm Hg者,UAER为(3.5±1.2) μg/min；31例脉压50 ～60 mm Hg者,UAER为(9.3±7.2) μg,/min；23例脉压60～70 mm Hg者,UAER为(29.6±32.1)g/min；52例脉压70 mm Hg以上者,UAER为(51.7±31.8) μg/min.随着脉压的增高,老年高血压患者的UAER也随之增高.结论 脉压可作为老年高血压患者肾损害的高危预测指标之一.