亚甲基四氢叶酸还原酶基因A1298C多态性与帕金森病易感性的Meta分析

摘要

目的：探讨亚甲基四氢叶酸还原酶（MTHFR）基因 A1298C 位点单核苷酸多态性（SNP）与帕金森病（PD）易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方数据库、维普信息资源系统，PubMed、Cochrane Library、OvidSP、Wiley Online Library、Springer Link、EBSCO、Elsevier Science Direct、Google scholar 数据库检索 MTHFR 基因 A1298C 位点 SNP 与 PD 相关的病例对照研究，利用 RevMan 5．3和 Stata 12．0软件，根据异质性大小选用随机效应或固定效应模型对各研究数据进行分析。结果共纳入8篇文献。Meta 分析结果提示 PD 组和对照组 AA 基因型[OR ＝0．92，95％CI：0．78～1．09，P ＝0．33]和 CC 基因型[OR ＝1．19，95％CI：0．89～1．59，P ＝0．23]、A 等位基因[OR ＝0．92，95％CI：0．81～1．04，P ＝0．19]和 C 等位基因[OR ＝1．09，95％CI：0．96～1．24，P ＝0．19]差异均无统计学意义。结论MTHFR 基因 A1298C 位点 SNP与 PD 易感性无关联性。%Objective To explore the association between A1298C polymorphism of methlenetetrahydrofolate reductase (MTHFR)gene and Parkinson's disease (PD)susceptibility.Methods The case-control studies of MTHFR gene and PD were selected from Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wanfang, Weipu,PubMed,Cochrane Library,OvidSP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link and Google scholar databases.The study data were analysed by random -effects or fixed -effects models depending on heter-ogeneity use RevMan 5.3 and Stata 12.0 software.Results Eight articles were included.The meta -analysis results suggested that there were no significant differences in genotype AA[OR =0.92,95%CI:0.78 -1.09,P =0.33],geno-type CC[OR =1.19,95%CI:0.89 -1.59,P =0.23],allele A[OR =0.92,95%CI:0.81 -1.04,P =0.19]and al-lele C[OR =1.09,95%CI:0.96 -1.24,P =0.19]between PD group and control group.Conclusion No relationship is found between the A1298C polymorphism of MTHFR gene and PD susceptibility.