吗啡联合二羟丙茶碱缓解晚期肿瘤患者呼吸困难的效果

摘要

目的 探讨吗啡联合二羟丙茶碱临床缓解晚期肿瘤患者呼吸困难的疗效.方法 用随机数字法将晚期肿瘤呼吸困难的186例患者分为2组,每组93例.对照组给予二羟丙茶碱,观察组在此基础上加用吗啡.比较两组呼吸困难情况[视觉模拟量表(VAS)评分、Brog量表]、血气指标[呼吸次数、心率(HR)及血氧饱和度(SpO2)]和临床疗效.结果 治疗后两组VAS、Brog评分、呼吸次数、HR显著降低,且观察组VAS、Brog、呼吸次数、HR显著低于对照组(P<0.05).治疗后两组SpO2显著升高,且观察组SpO2[(90.55 ±22.57)%]显著高于对照组[(79.51 ±19.57)%],t=3.564,P<0.05.观察组有效率为84.95%,显著高于对照组的34.41%,χ2=49.354,P<0.05.结论 吗啡联合二羟丙茶碱可有效缓晚期肿瘤患者呼吸困难,改善血气指标,治疗效果满意.%Objective To investigate the efficacy of morphine combined diprophyllineon advanced cancer patients with dyspnea.Methods 186 advanced tumor patients withdyspnea were divided into two groups by random number meth-od,each group 93 cases.The control group was given diprophylline,and observation group was given morphine based on control group.The dyspneaindex(VAS score,Brog scale),blood gas index(respiratory rate,SpO2,HR)and clinical effi-cacy of two groups were compared.Results After treatment,the VAS,Brog score,respiration rate and HR of two groups were significantly decreased(P<0.05)and VAS,Brog score,respiration rate and HR of observation group were signifi-cantly lower than those of control group(P<0.05).After treatment,the SpO2of two groups was significantly increased(P<0.05),the SpO2ofobservation group[(90.55 ±22.57)%]was significantly higher than that of control group [(79.51 ±19.57)%],t=3.564,P<0.05.The effective rate ofobservation group was 84.95%,which was significantly higher than that of control group(34.41%),χ2=49.354,P<0.05.Conclusion Morphine combined diprophylline could effectively relieve dyspnea of patients with advanced cancer and improve blood gas index.