氟哌噻吨美利曲辛联合谷维素对首发脑梗死老年患者生活质量与焦虑抑郁情绪的影响

摘要

目的 探讨氟哌噻吨美利曲辛与谷维素对首发脑梗死老年患者生活质量和焦虑抑郁情绪的影响.方法 将90例首发脑梗死老年患者根据随机数字法分氟哌噻吨美利曲辛组(27例)、谷维素组(28例)和氟哌噻吨美利曲辛联合谷维素联合治疗组(35例),4周疗程后比较治疗前后各组患者的生活质量和焦虑抑郁情绪的变化.结果 治疗后氟哌噻吨美利曲辛组、谷维素组和联合治疗组的生理功能、躯体疼痛、总体健康、活力、社会功能、精神健康、生理职能、情感职能等生活质量评价指标评分均明显比治疗前高,差异均有统计学意义(P＜0.05).组间比较,联合治疗组在治疗后生理功能、躯体疼痛、总体健康、活力、社会功能、精神健康、生理职能、情感职能等生活质量评价指标的评分均要明显高于氟哌噻吨美利曲辛组和谷维素组,差异有统计学意义(P＜0.05).治疗后谷维素组、氟哌噻吨美利曲辛组、联合治疗组的HAMD评分依次降低,差异有统计学意义(P＜0.05),治疗后氟哌噻吨美利曲辛组和谷维素组的HAMA评分均明显高于联合治疗组,差异有统计学意义(t =3.054,P=0.003;t=6.140,P＜0.001).结论 氟哌噻吨美利曲辛与谷维素联合治疗首发脑梗死老年患者可以明显改善患者的生活质量,降低患者的焦虑和抑郁情绪,具有较好的临床应用价值.%Objective To study the effect of deanxit combined with oryzanol injection on life quality,anxiety and depression in elderly cerebral infarction patients.Methods 90 elderly cerebral infarction patients were divided into deanxit group (27 cases)(Group A),oryzanol injection group (28 cases) (Group B) and deanxit joint oryzanol injection combined treatment group (35 cases) (Group C) according random number method during August 2012 to March 2015.Aher four weeks of treatment,life quality,anxiety and depression were compared in each group before and after treatment.Results After treatment,the score of physiological function,bodily pain,general health,vitality,social functioning,mental health,physical function,emotional function in Group A,Group B and Group C were significantly higher than before treatment (P ＜ 0.05).After treatment,the score of physiological function,body pain,general health,vitality,social functioning,mental health,physical function,emotional function in Group C were significant higher than Group A and Group B (P ＜ 0.05).The score of HAMD and HAMA after treatment in the Group C was the lowest among the three groups (P ＜ 0.05).Conclusion Deanxit combined with oryzanol injection can significantly improve the life quality and reduce patient anxiety and depression in patients wiith first elderly cerebral infarction.